Strategies to restore the brain’s sensitivity to leptin.
What the evidence says
- Lustig’s review argues, in modal language throughout, that hyperinsulinaemia ”can instead be primary, due to autonomic dysfunction”, that ”it seems that insulin functions as an endogenous leptin antagonist”, and that the First Law ”can be reinterpreted”[1]
- Suppressing insulin ameliorates leptin resistance, ”with ensuing reduction of caloric intake, increased spontaneous activity, and improved quality of life” — the review’s own sentence[1]
- The proposed reframing: increased caloric intake and decreased energy expenditure are secondary to obligate weight gain rather than its cause[1]
- Exposed to the same environment, some children gain weight and others do not[1]