Research paper
Lim JS, Mietus-Snyder M, Valente A, Schwarz JM, Lustig RH. The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome. Nature Reviews Gastroenterology & Hepatology. 2010 May;7(5):251-64. doi:10.1038/nrgastro.2010.41. PMID: 20368739.
Why we cite it
Highly cited review (755+ citations) proposing a unified "two-hit" framework for fructose-induced NAFLD: the first hit drives lipid accumulation through DNL and β-oxidation inhibition, while the second hit drives inflammation through protein fructosylation (Maillard reaction) and reactive oxygen species. Uniquely draws the biochemical parallel between fructose and ethanol hepatic metabolism, arguing both follow the same pathogenic pathway to steatohepatitis. This fructose-ethanol analogy is the primary contribution not found in the other csf citations.