Research paper
Softic S, Cohen DE, Kahn CR. Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease. Digestive Diseases and Sciences. 2016 May;61(5):1282-93. doi:10.1007/s10620-016-4054-0. PMID: 26856717. PMCID: PMC4838515.
Why we cite it
Comprehensive review linking fructose metabolism to NAFLD through de novo lipogenesis. Provides the detailed enzymatic pathway from fructose ingestion through triglyceride formation, quantifies historical fructose consumption trends, and explains key mechanisms absent from the other csf citations: ATP depletion (within 5 minutes of fructose load), selective insulin resistance (insulin continues promoting DNL while failing to suppress gluconeogenesis), and SREBP1c activation independent of insulin signaling. Establishes that DNL, not dietary fat uptake, is the primary metabolic difference between NAFLD and non-NAFLD individuals.
DOI: 10.1007/s10620-016-4054-0 · PubMed 26856717 · Publisher