Research paper
Softic S, Cohen DE, Kahn CR. Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease. Digestive Diseases and Sciences. 2016 May;61(5):1282-93. doi:10.1007/s10620-016-4054-0. PMID: 26856717. PMCID: PMC4838515.
Why we cite it
A review linking fructose metabolism to NAFLD through de novo lipogenesis. Provides the detailed enzymatic pathway from fructose ingestion through triglyceride formation, quantifies historical fructose consumption trends, and explains three mechanisms: ATP depletion (within 5 minutes of fructose load), selective insulin resistance (insulin continues promoting DNL while failing to suppress gluconeogenesis), and SREBP1c activation independent of insulin signaling. Argues that enhanced DNL is ”A central abnormality in NAFLD”. In the tracer study it relies on, the dietary share of liver triglyceride did not differ (5% in both groups), the plasma-FFA share was lower in the high liver-fat group (38% vs 52%), and the DNL share was higher (23% vs 10%).
DOI: 10.1007/s10620-016-4054-0 · PubMed 26856717 · Publisher
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