Research paper
Basaranoglu M, Basaranoglu G, Sabuncu T, Sentürk H. Fructose as a key player in the development of fatty liver disease. World Journal of Gastroenterology. 2013 Feb 28;19(8):1166-72. doi: 10.3748/wjg.v19.i8.1166
Why we cite it
Provides quantitative data on how dramatically de novo lipogenesis is elevated in NAFLD patients (26% of hepatic triglycerides vs <5% in healthy subjects) and identifies the specific stress pathway (JNK) by which fructose impairs hepatic insulin signaling. Also demonstrates the synergistic harm of combining fructose with high-fat diets — producing fibrosis, inflammation, and ER stress that neither fructose nor fat alone generates.