Research paper
Weigle DS, Breen PA, Matthys CC, Callahan HS, Meeuws KE, Burden VR, Purnell JQ. A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations. Am J Clin Nutr. 2005;82(1):41-48.
Why we cite it
Demonstrates that increasing dietary protein from 15% to 30% of energy produces a sustained ~441 kcal/day spontaneous reduction in caloric intake over 12 weeks, with 4.9 kg of weight loss — and that this appetite suppression occurs despite compensatory decreases in leptin and increases in ghrelin that would normally drive hunger upward. Its three-phase design isolated the protein effect: appetite decreased during the isocaloric high-protein phase (same calories, different ratio) before subjects were allowed to eat freely. Gosby et al. 2011 tested the opposite direction, low protein driving overconsumption.
Known defects on this page:
- Most reference pages are missing their About the authors section Most of our reference pages leave out the section about who wrote the paper