Research paper
Wang A, Huen SC, Luan HH, Yu S, Zhang C, Gallezot JD, Booth CJ, Medzhitov R. Opposing effects of fasting metabolism on tissue tolerance in bacterial and viral inflammation. Cell. 2016 Sep 8;166(6):1512-1525.e12. doi:10.1016/j.cell.2016.07.026
Why we cite it
Demonstrates that the metabolic strategy for surviving infection differs fundamentally by pathogen type: fasting protects in bacterial sepsis while feeding/glucose protects in viral infections. Provides a mechanistic basis for infection-associated anorexia as an adaptive response, with implications for how nutrition during illness should be understood.
DOI: 10.1016/j.cell.2016.07.026 · PubMed 27610573 · Publisher