Research paper
Rosenbaum M, Leibel RL. Adaptive thermogenesis in humans. International Journal of Obesity. 2010;34 Suppl 1:S47-55. doi:10.1038/ijo.2010.184. PMID: 20935667. PMCID: PMC3673773.
Why we cite it
Authoritative review from the laboratory that co-discovered leptin, documenting the coordinated metabolic, neuroendocrine, autonomic, and behavioral responses to weight loss that create an "optimal biological circumstance for weight regain." Provides specific magnitudes (TEE -20-25%, SNS -40%, muscle efficiency +20%, 300-400 kcal/day penalty) and demonstrates that leptin repletion to pre-weight-loss levels reverses most of these changes.