Research paper
Sutton EF, Beyl R, Early KS, Cefalu WT, Ravussin E, Peterson CM. Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes. Cell Metabolism. 2018 Jun 5;27(6):1212-1221.e3. doi:10.1016/j.cmet.2018.04.010
Why we cite it
Provides controlled human evidence that intermittent fasting confers metabolic benefits independent of weight loss — **the authors state theirs was the first such trial** (*"Our trial was the first randomized controlled…"*) — **in 8 men who completed, of 12 enrolled**. By feeding participants enough food to maintain their weight (isocaloric design), the study isolates meal timing as the active variable and demonstrates that aligning eating with circadian rhythms — eating early and finishing by mid-afternoon — improves insulin sensitivity, blood pressure, and oxidative stress in men with prediabetes. This is directly relevant to the project because it separates the effects of when you eat from how much you eat, providing clinical evidence for the circadian alignment principle underlying time-restricted eating recommendations.
**Sample added to the opening claim, 2026-09-02 (card SP97Y7).** The section's verbs are right for the design — this **is** a randomised crossover trial with an isocaloric arm, so *"demonstrates"* and *"controlled evidence"* are earned, and the population was already named mid-paragraph. **What was missing is that "the first controlled human evidence" rests on 8 completers of 12 enrolled**, and that phrase is the one a page will quote.
**No mode correction needed here.** Recorded as checked rather than left silent, so the next reader knows this Contribution was audited and passed on its verbs.
DOI: 10.1016/j.cmet.2018.04.010 · PubMed 29754952 · Publisher