Research paper
Minihane AM, Vinoy S, Russell WR, Baka A, Roche HM, Tuohy KM, Teeling JL, Blaak EE, Fenech M, Vauzour D, McArdle HJ, Kremer BHA, Sterkman L, Vafeiadou K, Benedetti MM, Williams CM, Calder PC. Low-grade inflammation, diet composition and health: current research evidence and its translation. British Journal of Nutrition. 2015 Oct 14;114(7):999-1012. doi:10.1017/S0007114515002093. PMID: 26228057; PMCID: PMC4579563.
Why we cite it
Comprehensive review (14 pages, 17 international co-authors) synthesising research from an ILSI Europe workshop on chronic low-grade inflammation, dietary modulation, and health outcomes. Covers three domains — cardiometabolic, gastrointestinal, and neurological — **reporting that diet composition *may* modulate inflammatory processes** across all three. Introduces the gut microbiota–inflammation axis (metabolic endotoxaemia, SCFA production) as a key mechanism linking diet to systemic inflammation. Identifies omega-3–derived specialised pro-resolving mediators (resolvins, protectins, maresins) as actively resolving inflammation rather than merely suppressing it. Critically, identifies that current biomarker approaches (fasting blood cytokines) are insensitive indices of tissue-level inflammation and advocates for challenge-based testing and multi-omics approaches. Relevant to companion 379 (inflammation connection) as the most comprehensive of the three inflammation citations, bridging dietary patterns to inflammatory mechanisms across multiple organ systems.
DOI: 10.1017/S0007114515002093 · PubMed 26228057 · Publisher