Research paper
Kishimoto I. Subclinical reactive hypoglycemia with low glucose effectiveness — why we cannot stop snacking despite gaining weight. Metabolites. 2023;13(6):754. doi:10.3390/metabo13060754. PMID: 37367911. PMCID: PMC10304473.
Why we cite it
Review paper proposing a physiological mechanism for why some overweight people cannot stop snacking despite gaining weight — subclinical reactive hypoglycemia (SRH). Using continuous glucose monitoring in obese/overweight men without diabetes — men only, Kishimoto reports that half — the paper’s word, twice — exhibit glucose below 70 mg/dL after a 75-g oral glucose load ”without notable hypoglycemic symptoms except hunger”, and that people with SRH snack more frequently than those without it. The causal loop is the author’s proposal and is hedged in his own abstract: a vicious cycle ”can be formed”, the data ”suggest” the Sg association, and prevention ”might be key”. The paper introduces glucose effectiveness (Sg) as the connecting mechanism — low Sg links SRH to snacking habits and obesity, while high Sg may break the cycle: ”Exercise training improves Sg”, and Sg ”is high in those with low-fat diets”, an association for diet. The paper says that snacking ”in certain conditions may not be self-controllable”.
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