Research paper
Berry SE, Valdes AM, Drew DA, Asnicar F, Mazidi M, Wolf J, Capdevila J, Hadjigeorgiou G, Davies R, Al Khatib H, Bonnett C, Sherber D, Linenberg I, Segata N, Franks PW, Spector TD. Human postprandial responses to food and potential for precision nutrition. Nat Med. 2020 Jun;26(6):964-973. doi:10.1038/s41591-020-0934-0
Why we cite it
The PREDICT 1 study extends Zeevi et al. 2015 by adding lipid and insulin responses alongside glucose, incorporating twin pairs to separate genetic from environmental factors, and finding ”wide variations in postprandial responses between people, even identical twins”. The heritability estimates are the finding and they vary by outcome rather than supporting one summary: in 230 twin pairs (n = 460; 183 monozygotic, 47 dizygotic), additive genetic factors explained 30% of the variance in glucose iAUC₀₋₂ₕ, but only 4% for the triglyceride 6-hour rise and 9% for the insulin 2-hour rise, with the estimates for insulin and C-peptide 1-hour rises close to zero. The quantification of variance explained by different factors (genetics, microbiome, meal composition, modifiable behaviors) provides a framework for understanding what matters most.
DOI: 10.1038/s41591-020-0934-0 · PubMed 32528151 · Publisher
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