Research paper
Longo VD, Panda S. Fasting, circadian rhythms, and time-restricted feeding in healthy lifespan. Cell Metabolism. 2016 Jun 14;23(6):1048-1059. doi:10.1016/j.cmet.2016.06.001. PMID: 27304506. PMCID: PMC5388543.
Why we cite it
Review providing a classification of fasting types (intermittent, periodic, time-restricted feeding) and their distinct biological mechanisms — which is the contribution, and is checkable against the paper. (Previously “Highly cited review (2,000+ citations)” and “the definitive classification”, corrected 2026-09-02, card 6NM98H: undated count, unsurveyable ranking.) Integrates circadian biology with fasting science, arguing that eating pattern timing — not just content or quantity — determines metabolic outcomes. Provides the FMD trial data (mouse and human) and quantitative TRF results. The fasting classification framework and the circadian-metabolic connection are the primary contributions not found in other fasting citations.
DOI: 10.1016/j.cmet.2016.06.001 · PubMed 27304506 · Publisher