Research paper
Carhuatanta KAK, Demuro G, Tschöp MH, Pfluger PT, Benoit SC, Obici S. Voluntary exercise improves high-fat diet-induced leptin resistance independent of adiposity. Endocrinology. 2011;152(7):2655-2664. doi:10.1210/en.2010-1340
Why we cite it
Provides mechanistic evidence from an animal model that voluntary exercise improves central nervous system leptin sensitivity through a pathway independent of fat mass reduction. The critical experimental design — comparing exercised mice with calorie-restricted mice matched for fat mass — shows, in these mice, that exercise does something calorie restriction alone did not: restore leptin’s ability to reduce body weight and activate leptin receptor-positive neurons in the ventromedial hypothalamus.
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