Research paper
Cummings DE, Overduin J. Gastrointestinal regulation of food intake. Journal of Clinical Investigation. 2007;117(1):13-23. doi:10.1172/JCI30227. PMID: 17200702. PMCID: PMC1716217.
Why we cite it
Comprehensive JCI review of gastrointestinal regulation of food intake covering the full spectrum of satiation peptides, the sole orexigenic hormone ghrelin, and taste-like nutrient sensing in enteroendocrine cells. Relevant to this project because it provides the mechanistic detail behind how the gut tells the brain to stop eating (and how ghrelin tells it to start), explains why chronic single-peptide approaches fail (compensatory meal frequency), how adiposity hormones act as gain-setters for satiation sensitivity, and why bariatric surgery succeeds through simultaneous modulation of multiple gut peptides.