Research paper
Williams EK, Chang RB, Strochlic DE, Umans BD, Lowell BB, Liberles SD. Sensory neurons that detect stretch and nutrients in the digestive system. Cell. 2016;166(1):209-221. doi:10.1016/j.cell.2016.05.011. PMID: 27238020.
Why we cite it
Cell paper, in mice, that genetically identified and functionally characterised two distinct vagal sensory neuron populations — GLP1R neurons (mechanoreceptors detecting stomach/intestinal stretch) and GPR65 neurons (chemoreceptors detecting intestinal nutrients via serotonin) — using in vivo calcium imaging, optogenetics, and Cre-based anatomical mapping. It shows, in mice, that stretch and nutrients reach the brainstem through genetically distinct vagal neuron populations, and that optogenetically activating the duodenal GPR65 neurons ”stopped or reduced gastric contractions”.
DOI: 10.1016/j.cell.2016.05.011 · PubMed 27238020 · Publisher
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