Research paper
Grill HJ, Hayes MR. Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance. Cell Metabolism. 2012;16(3):296-309. doi:10.1016/j.cmet.2012.06.015. PMID: 22902836.
Why we cite it
Review arguing, in its title’s words, for hindbrain neurons, the NTS above all, as ”an essential hub in the neuroanatomically distributed control of energy balance”, challenging a hypothalamic-centric model. It describes satiety as a multi-level process: decerebrate and anencephalic cases give ”conclusive support for the sufficiency of caudal brainstem circuits in ingestive consummatory response control”, the review covers ”the role that descending projections from forebrain structures have on NTS-mediated processes”, and it calls ”novel” the idea that gut satiation signals ”can modulate the rewarding value of food via direct NTS-relayed monosynaptic projections” to the VTA and NAc.
DOI: 10.1016/j.cmet.2012.06.015 · PubMed 22902836 · Publisher
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