Research paper
Alirezaei M, Kemball CC, Flynn CT, Wood MR, Whitton JL, Kiosses WB. Short-term fasting induces profound neuronal autophagy. Autophagy. 2010 Aug 16;6(6):702-710. doi:10.4161/auto.6.6.12376. PMID: 20534972. PMCID: PMC3106288.
Why we cite it
A study in transgenic mice showing that short-term fasting upregulates autophagy in brain neurons, against what the paper calls the ”current dogma” that ”the brain escapes this effect, perhaps because it is a metabolically privileged site”. Using GFP-LC3 transgenic mice and confocal microscopy combined with transmission electron microscopy, it shows increased neuronal autophagosomes after food restriction: a ~4-fold increase in Purkinje autophagosome number (p < 0.0002) and a >3-fold neurite signal at 24 hours (p = 0.004), in mice restricted for 24 or 48 hours, with diminished neuronal mTOR activity. It is a mouse study.
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