Research paper
Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell. 2008 Jan 11;132(1):27-42. doi:10.1016/j.cell.2007.12.018. PMID: 18191218. PMCID: PMC2696814.
Why we cite it
A review in Cell of the role of autophagy across the major categories of disease. It sets out a framework for understanding autophagy: cells identify damaged components, encapsulate them in autophagosomes, and degrade them via lysosomal fusion for recycling. Covers autophagy in neurodegeneration, cancer, ageing, infection/immunity, cardiac disease, liver disease, and muscle disease. It addresses disease pathogenesis rather than fasting-specific induction.
DOI: 10.1016/j.cell.2007.12.018 · PubMed 18191218 · Publisher
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