The setpoint isn’t permanently fixed — it can change in both directions. Research by Speakman shows it drifts upward through chronic processed food consumption, constant eating, and poor sleep. It can be lowered through fasting, reduced insulin exposure, improved food quality, and time at a lower weight. The goal isn’t to overpower your body’s regulation system forever — it’s to change what your body defends.
This companion covers what raises the setpoint, what lowers it, and practical implications. (3 min read)