Research paper
Trexler ET, Smith-Ryan AE, Norton LE. Metabolic adaptation to weight loss: implications for the athlete. J Int Soc Sports Nutr. 2014;11(1):7. doi:10.1186/1550-2783-11-7. PMID: 24571926. PMCID: PMC3943438.
Why we cite it
Narrative review in *JISSN* (open access) synthesizing the mechanisms of metabolic adaptation to weight loss across three domains: endocrine responses (coordinated hormonal shifts promoting energy conservation), energy expenditure changes (adaptive thermogenesis exceeding predicted declines, NEAT suppression), and mitochondrial efficiency (reduced proton leak, decreased UCP expression). Uniquely frames these adaptations in the context of athletes pursuing very low body fat levels and offers practical strategies for mitigating adaptation. Referenced in companion 434 for comprehensive overview of metabolic adaptation mechanisms and practical strategies.