Research paper
Rosenbaum M, Sy M, Pavlovich K, Leibel RL, Hirsch J. Leptin reverses weight loss–induced changes in regional neural activity responses to visual food stimuli. J Clin Invest. 2008 Jul;118(7):2583-2591. doi:10.1172/JCI35055. PMID: 18568078. PMCID: PMC2430499.
Why we cite it
An influential fMRI study (approximately 407 Semantic Scholar citations) providing direct neuroimaging evidence that weight loss alters brain responses to food cues in ways that favor increased food intake, and that these changes are reversed by leptin repletion to pre-weight-loss levels. Bridges the gap between metabolic observations of adaptive thermogenesis (cls02) and the neural mechanisms underlying increased food-seeking behavior after weight loss.