Research paper
Schwartz GJ. The role of gastrointestinal vagal afferents in the control of food intake: current prospects. Nutrition. 2000 Oct;16(10):866-73. doi:10.1016/s0899-9007(00)00464-0. PMID: 11054591.
Why we cite it
Review examining the vagal gut-brain axis in the negative-feedback control of meal size from four complementary perspectives: neuroanatomic, neurophysiologic, molecular, and behavioral. Relevant to this project because it synthesises the pre-genetics era understanding of how vagal afferents detect meal-related stimuli (mechanical, chemical, and peptide), relay them viscerotopically to the caudal brainstem, and how centrally acting neuropeptides can modulate this processing — laying the groundwork for the genetics-based approaches that followed (e.g., Williams et al. 2016, cbs04).
About the author
Gary J. Schwartz, PhD, is Professor of Medicine (Endocrinology), Neuroscience, and Psychiatry at Albert Einstein College of Medicine; Principal Investigator of the Skirball Institute for Nutrient Sensing; Director of the Einstein-Mount Sinai Diabetes Research Center Animal Physiology Core. BA in Psychology from Johns Hopkins University (1982); PhD in Psychology from the University of Pennsylvania (1986, under Harvey Grill — see cbs02); previously at the Edward W. Bourne Behavioral Research Laboratory, Weill Medical College of Cornell University; 278 publications; ~19,700 citations; editorial boards of Diabetes and Endocrinology; Associate Editor of American Journal of Physiology (Endocrinology & Metabolism).