Research paper
Pepino MY. Metabolic effects of non-nutritive sweeteners. Physiology & Behavior. 2015 Dec 1;152(Pt B):450-455. doi:10.1016/j.physbeh.2015.06.024. PMCID: PMC4661066.
Why we cite it
Integrative review presenting three non-mutually-exclusive mechanisms by which “metabolically inactive” NNS may promote metabolic dysregulation. Alongside the learning-based mechanism (Swithers) and the microbiome mechanism (Suez et al.), it sets out a sweet-taste receptor mechanism (T1R2/T1R3 signaling in gut and pancreas affecting glucose absorption and insulin secretion). It also reports that individual taste sensitivity to sucralose correlates with its acute metabolic effects — suggesting shared signaling pathways between oral and gut sweet-taste responses.
About the author
M. Yanina Pepino was at the Center for Human Nutrition, Washington University School of Medicine when this review was written; now Associate Professor of Food Science and Human Nutrition at the University of Illinois. She works on taste perception, artificial sweeteners, and metabolic responses.
DOI: 10.1016/j.physbeh.2015.06.024 · PubMed 26095119 · Publisher